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In a new review (Neurobiol Dis. 2022 Oct 15; 105897. doi: 10.1016/j.nbd.2022.105897) the authors explore the effect of gut microbiota manipulation as a therapeutic strategy in epilepsy and the methodological challenges to design (translational) clinical trial investigating the gut microbiota

A weighted blanket of approximately 12% body weight used at bedtime prompted the release of higher concentrations of melatonin, as measured in the saliva, compared with a lighter blanket of only about 2.4% of body weight in a new study.

The factor that is most relevant and strongly associated with the clinical course of multiple sclerosis is chronological age. Very young patients almost exclusively have relapsing remitting disease, whereas those with later onset disease face a more rapid development of permanent disability.

Pregnant women with gestational hypertension and preeclampsia/eclampsia had a higher risk for vascular dementia later in life, though they showed no significant excess risk for Alzheimer's disease, according to a study that retrospectively tracked women over an 80-year period.