A flower to Fight Alzheimer’s

Phyllodulcin, a natural sweetener found in Hydrangea macrophylla var. thunbergii, shows potential for treating Alzheimer's disease (AD).

A new study (Biomedicine & Pharmacotherapy journal) demonstrates that phyllodulcin inhibits the aggregation of amyloid β (Aβ), a main cause of AD, and decomposes existing Aβ clumps. In an animal model, phyllodulcin reduced memory impairments, decreased deposition of Aβ in the hippocampus, and minimized neuroinflammation, key factors in AD.

These findings suggest that phyllodulcin could offer a promising new avenue for AD treatment.

The study indicates that phyllodulcin, a natural sweetener, inhibits amyloid β (Aβ) aggregation, a leading cause of Alzheimer's disease, and decomposes pre-existing Aβ clumps.

The research used both in vitro (cells) and in vivo (animal model) experiments, demonstrating that phyllodulcin also prevents Aβ-induced neurotoxicity.

In an AD animal model, phyllodulcin reduced memory impairments, decreased Aβ deposition in the hippocampus, and minimized neuroinflammation, all critical elements of AD.